IL-6/IL-6R as a potential key signaling pathway in prostate cancer development

• 作 者: Andreia Azevedo Virginia Cunha
• 机 构: MolecularOncologyandVirology,ResearchDepartmentofPortugueseLeagueagainstCancer（NRNorte）,CEBIMED,ICBA
• 出 处: 世界临床肿瘤学杂志
• 发表日期: 2011年12期
• 关键词: Androgen RECEPTOR CASTRATION-RESISTANT PROSTATE CANCER HORMONAL CASTRATION Inteu
• 基金项目: Supported by Calouste Gulbenkian Foundation(Oncology/2008/Project n 96736)and Science and Technology Foundation(FCT/PTDC/SAU-FCF/71552/2006).

Interleukin-6(IL-6)is a pleiotropic cytokine involved in prostate regulation and in prostate cancer(PC)development/progression.IL-6 acts as a paracrine and autocrine growth stimulator in benign and tumor prostate cells.The levels of IL-6 and respective re