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目的:观察急性心肌梗死经皮冠状动脉内介入治疗患者血糖原合成酶激酶-3β及心钠素前体肽的水平变化。方法:分别应用PCR法、WB法和放射免疫法检测145例急性心肌梗死患者入院时和术后1,3,7 d及对照组的心钠素前体肽1-30,31-67,79-98和糖原合成酶激酶-3β水平。结果:急性心肌梗死组患者糖原合成酶激酶3β与心钠素前体胎水平较对照组明显升高。急性心肌梗死组患者术后糖原合成酶激酶-3βmRNA水平较术前明显升高,心钠素前体肽水平较术前显著升高,术后2周上述指标恢复术前水平以下。结论:急性心肌梗死介入治疗患者血糖原合成酶激酶-3β与心钠素前体肽水平呈先上升后下降的趋势。
Objective: To observe the changes of glycogen synthase kinase-3β and atrial natriuretic peptide in patients undergoing percutaneous coronary intervention with acute myocardial infarction. Methods: PCR, WB and radioimmunoassay were used to detect the expression of atrial natriuretic peptide 1 -30, 31-67, 79 in 145 patients with acute myocardial infarction -98 and glycogen synthase kinase-3β levels. Results: The levels of glycogen synthase kinase 3β and atrial natriuretic peptide in acute myocardial infarction group were significantly higher than those in control group. The level of glycogen synthase kinase-3βmRNA in acute myocardial infarction group was significantly higher than that before operation, and the level of atrial natriuretic peptide was significantly higher than that before operation. The above indexes recovered to the level below preoperative level 2 weeks after operation. CONCLUSION: The levels of glycogen synthase kinase-3β and atrial natriuretic peptide in patients with acute myocardial infarction tend to increase at first and then decrease.