论文部分内容阅读
目的探讨吸入一氧化氮(Nitric oxide,NO)对婴幼儿体外循环手术中环磷酸鸟苷(cGMP)、细胞间粘附分子-1(ICAM-1)的影响及意义。方法将104例患室间隔缺损的婴幼儿随机分为对照组和NO组,NO组在体外循环期间吸入40 ppm NO直至关胸。在体外循环前、主动脉开放后1、3、5、10min分别取右上肺静脉血和右心房血用于cGMP、ICAM-1的测定。同时采集动脉血行血气分析,计算动脉血氧含量(CaO2)、动脉血氧饱和度(SaO2)。结果NO组cGMP、SaO2和PaO2水平较对照组增高(P<0.01),ICAM-1则较对照组明显降低(P<0.05)。结论NO能抑制白细胞的粘附、聚集和激活,改善肺微循环,从而减轻体外循环并发症。
Objective To investigate the effects of nitric oxide (NO) on cGMP and ICAM-1 during cardiopulmonary bypass in infants and young children. Methods 104 infants with ventricular septal defect were randomly divided into control group and NO group. NO group inhaled 40 ppm NO during cardiopulmonary bypass until the chest closed. Before cardiopulmonary bypass, 1, 3, 5, 10 min after the aorta was opened, right upper pulmonary vein and right atrial blood were taken for the determination of cGMP and ICAM-1. At the same time, arterial blood gas analysis was collected to calculate the arterial oxygen content (CaO2), arterial oxygen saturation (SaO2). Results The levels of cGMP, SaO2 and PaO2 in NO group were significantly higher than those in control group (P <0.01), while those in ICAM-1 group were significantly lower than those in control group (P <0.05). Conclusion NO can inhibit leukocyte adhesion, aggregation and activation, improve pulmonary microcirculation, thereby reducing the complications of extracorporeal circulation.