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用生物活性法，检测人类疱疹病毒7型Glasgow株和南京地方株YY5及HHV-6GS株感染单个核细胞培养上清中肿瘤坏死因子－α（TNF-α）的水平。结果发现，HHV-7对也能较强地诱生TNF-α，但达到峰值时间（3～4d）迟于HHV-6GS株（2d）；在感染24h上请中，GS株产生TNF-α量明显多于YY5株、Glasgow株产生量（P＜0．05），三者与未感染单个核细胞比较都存在显著差异（P＜0．05），但Glasgow珠和YY5株之间无差异（P＞0．05）。结果表明，HHV-6、HHV-7都能通过刺激单个核细胞产生TNF-α而发挥免疫调节功能。
The level of tumor necrosis factor-α (TNF-α) in culture supernatant of mononuclear cells was detected by bioassay in human Gosling strain 7 Glasgow and Nanjing local strains YY5 and HHV-6GS. The results showed that HHV-7 could induce TNF-α more strongly, but peaked at 3 ~ 4d later than that of HHV-6GS (2d) (P <0.05). There was a significant difference (P <0.05) between the three strains and uninfected mononuclear cells, but there was no significant difference between Glasgow beads and YY5 strains (P> 0.05). The results showed that both HHV-6 and HHV-7 could play an immunomodulatory role by stimulating mononuclear cells to produce TNF-α.