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目的评估地佐辛静脉注射在人工流产手术中镇痛的有效性及安全性。方法前瞻性入组2012年3月-2014年5月240例自愿在该院行人工流产手术终止妊娠的早孕妇女,按照自愿原则分为A、B、C 3组,每组80例,分别予以地佐辛、异丙酚静脉注射镇痛以及无镇痛措施。术中、术后0.5 h及术后1 h分别对患者进行VAS评分;同时记录术中血压、心率、血氧饱和度、手术时间、停药后离院时间、不良反应以及手术镇痛费用情况等。结果 C组的手术时间明显长于A、B两组,差异有统计学意义(F=36.077,P<0.001)。B组停药后离院时间最长,术中出血量最多,差异有统计学意义(F=39.682,P<0.001;F=44.492,P<0.001)。A组术中VAS评分明显低于C组(χ~2=110.396,P<0.001);术后0.5 h A组VAS评分最低,B组VAS评分最高(χ~2=104.323,P<0.001);而术后1 h 3组VAS评分比较,差异无统计学意义(χ~2=2.233,P=0.327)。C组轻微恶心的发生率明显高于B组(χ~2=6.204,P=0.045),而B组过敏反应发生率明显高于A、C两组(χ~2=10.213,P=0.006)。A组的疼痛费用仅为B组的22.9%。结论人工流产手术中予以地佐辛静脉注射镇痛镇静效果明显且持续时间长、并发症少、社会经济效益好。
Objective To evaluate the efficacy and safety of intravenous dezocine injection in induced abortion. Methods From March 2012 to May 2014, 240 pregnant women who voluntarily performed termination of induced abortion in this hospital were divided into A, B and C groups according to the voluntary principle, 80 cases in each group, respectively Dezocine, propofol intravenous analgesia and no analgesic measures. VAS score was recorded at 0.5 h and 1 h after surgery respectively. Meanwhile, blood pressure, heart rate, blood oxygen saturation, operation time, hospital stay after hospitalization, adverse reactions and cost of operation analgesia were recorded Wait. Results The operation time of group C was significantly longer than that of group A and B (F = 36.077, P <0.001). The patients in group B had the longest stay after hospitalization and the most blood loss during operation. The difference was statistically significant (F = 39.682, P <0.001; F = 44.492, P <0.001). The VAS score of group A was lower than that of group C (χ ~ 2 = 110.396, P <0.001). The VAS score of group A was the lowest at 0.5 h after operation, and the VAS score of group B was the highest (χ ~ 2 = 104.323, There was no significant difference in VAS score between 1 h and 3 h postoperatively (χ ~ 2 = 2.233, P = 0.327). The incidence of mild nausea in group C was significantly higher than that in group B (χ ~ 2 = 6.204, P = 0.045), while the incidence of allergic reactions in group B was significantly higher than that in groups A and C (χ ~ 2 = 10.213, . The pain cost in group A was only 22.9% in group B. Conclusion Induction of intravenous dezocine intravenous injection during induced abortion has obvious effect and long duration, few complications and good social and economic benefits.