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研究乳猪肾提取液对大鼠庆大霉素肾毒性的防治作用。新鲜乳猪肾经匀浆、超滤等处理得肾提取液。肌注庆大霉素100mg／（kg·d）×7d制成大鼠急性肾衰模型。制模同时及造模后分别ip肾提取液15mg／（kg·d），观察大鼠血清尿素氮（Bloodureanitrogen，BUN）、肌酐（Cr）及肾组织变化情况。实验结束时，预防组BUN为9．30±2．60mmol/L，Cr为125．00±26．60μmol／L；模型组BUN为12.80±2.45mmol／L，Cr为167．00±39．60μmol／L，P＜0．01。结果表明，肾提取液可明显减轻庆大霉素对大鼠的肾损害。
To study the preventive and therapeutic effects of sucking pig’s kidney extract on gentamicin nephrotoxicity in rats. Fresh piglets kidney homogenate, ultrafiltration and other treatment of kidney extract. Intramuscular injection of gentamycin 100mg / (kg · d) × 7d rat acute renal failure model. At the same time and after modeling, ip kidney extract 15mg / (kg · d) respectively, and the changes of blood urea nitrogen (BUN), creatinine (Cr) and renal tissue in rats were observed. At the end of the experiment, the BUN in the prophylaxis group was 9.30 ± 2.60 mmol / L, the Cr was 125.00 ± 26.60 μmol / L in the prophylaxis group, the BUN in the model group was 12.80 ± 2.45 mmol / L, and the Cr was 167.00 ± 39.60 μmol /L,P<0.01. The results show that the kidney extract can significantly reduce the gentamicin on rats with renal damage.