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目的探讨联用抗抑郁药治疗消化性溃疡的临床疗效。方法以2002年6月至2004年5月洛阳市第三人民医院消化内科收治的121例消化性溃疡患者为观察对象。随机分为两组,甲组单用内科常规治疗,乙组采用内科治疗合并小剂量抗抑郁药治疗。所有入组患者在治疗前后由精神科医师进行汉密顿抑郁量表和汉密顿焦虑量表的评分,同时针对乙组患者的心理状态进行心理干预,由消化内科医师观察两组在疗效上的差异并进行评定。结果1乙组患者(同时给予内科治疗和小剂量抗抑郁药氟西汀10~20mg治疗的患者)在治疗1个月后焦虑抑郁症状明显改善,与甲组(仅给予内科治疗的患者)相比,存在显著性差异(P<0.01)。2乙组在治疗1个月后有效率为96.7%,甲组为88.3%,乙组明显高于甲组(P<0.01)。结论消化性溃疡患者大都有一定的焦虑抑郁心理障碍,在积极进行内科治疗的同时,合并小剂量抗抑郁药氟西汀10~20mg/d,能更好地提高疗效,促进溃疡的愈合。
Objective To explore the clinical efficacy of antidepressants in the treatment of peptic ulcer. Methods A total of 121 patients with peptic ulcer admitted to Department of Gastroenterology, Third People ’s Hospital of Luoyang City from June 2002 to May 2004 were observed. Randomly divided into two groups, Group A with conventional medical treatment, Group B with medical treatment combined with low-dose antidepressants. All patients were assessed by psychiatrists before and after treatment by the Hamilton Depression Scale and the Hamilton Anxiety Scale, psychological intervention in patients with Group B psychological intervention by the digestive physician to observe the two groups in the efficacy Differences and assessment. Results In group B, the symptoms of anxiety and depression were significantly improved after 1 month of treatment in patients treated with both medical therapy and low-dose anti-depressant fluoxetine (10-20 mg), and group A (patients receiving only medical therapy) There was significant difference (P <0.01). The effective rate of group B in one month after treatment was 96.7%, in group A was 88.3%, in group B was significantly higher than that in group A (P <0.01). Conclusions Most patients with peptic ulcer have some psychological disorder of anxiety and depression. In combination with active medical treatment, small doses of fluoxetine 10 ~ 20mg / d can improve the curative effect and promote ulcer healing.