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目的 提高对颅内混合瘤的CT、MRI表现与病理相关知识的认识。方法 12例经CT、MRI检查及手术光镜诊断 ,其中 5例作透射电镜肿瘤超微结构和免疫组化染色检查肿瘤相关抗原 (GFAP、Vimentin、S 10 0、FVⅢ因子 )。结果 脑膜瘤和胶质母细胞瘤 5例 ,脑膜瘤和垂体瘤 2例 ,胶质母细胞瘤和脑膜瘤、垂体瘤和脑膜瘤、胶质母细胞瘤和血管母细胞瘤、胶质母细胞瘤和血管内皮瘤、胆脂瘤和脑膜黑色素瘤各 1例。胶质母细胞瘤GFAP强阳性 ,S 10 0弱阳性 ;脑膜瘤Vimentin弱阳性 ,血管母细胞瘤和血管内皮瘤强阳性。结论 CT、MRI应结合临床上病程短 ,发展快等特点诊断本肿瘤。
Objective To improve the knowledge of CT and MRI manifestations and pathology of intracranial mixed tumor. Methods Twelve cases were diagnosed by CT, MRI and operation light microscope. Among them, 5 cases were examined by transmission electron microscopy and immunohistochemical staining for tumor associated antigens (GFAP, Vimentin, S 10 0, FVIII factor). Results Five cases of meningioma and glioblastoma, two cases of meningioma and pituitary tumor, glioblastoma and meningioma, pituitary tumor and meningioma, glioblastoma and hemangioblastoma, glioblastoma Tumor and hemangioendothelioma, cholesteatoma and meningioma in 1 case. Glioblastoma GFAP strongly positive, S 10 0 weakly positive; meningioma Vimentin weakly positive, hemangioblastoma and hemangioendothelioma strongly positive. Conclusion CT and MRI should be combined with clinical short course, rapid development of the diagnosis of the tumor.