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氯丙嗪为一抗精神病药,其副作用为,可致血压下降,甚至出现低血压休克,静脉注射尤甚。对此,不宜用α、β受体兴奋药肾上腺素治疗。这是因为α受体主要分布于血管,当其兴奋时,血管收缩,外周阻力增加,血压上升。β受体分β_1和β_2两个亚型,β_1主要分布于心肌,当β_1受体兴奋时,心肌收缩力加强,心输出量增加,表现为血压(主要是收缩压)升高;β_2主要分布于平滑肌,当β_2受体兴奋时,血管扩张表现为血压(主要是舒张压)下降。氯丙嗪可阻断α受体,兴奋
Chlorpromazine as an antipsychotic, its side effects, can lead to decreased blood pressure, and even hypotensive shock, especially intravenous injection. In this regard, should not be used α, β receptor agonist adrenaline treatment. This is because α receptors are mainly located in blood vessels, when excited, vasoconstriction, increased peripheral resistance, blood pressure. β receptor is divided into two subtypes β_1 and β_2. β_1 is mainly distributed in the myocardium. When the β_1 receptor is excited, the myocardial contractility is strengthened and the cardiac output is increased, showing the increase of blood pressure (mainly systolic pressure). The main distribution of β_2 In smooth muscle, vasodilation appears as a decrease in blood pressure (mainly diastolic pressure) when β_2 receptor is excited. Chlorpromazine blocks alpha receptors and is excited