论文部分内容阅读
AIDS是严重危害人类健康的疾病,而HIV是导致这种疾病的病毒。gp41六螺旋在介导HIV-1病毒与靶细胞间的膜融合过程中起着重要作用。因此,对于gp41结合蛋白的研究有助于深入了解gp41在HIV-1感染整个过程中扮演的角色,解释gp41对靶细胞的调控机制,为寻找新的抗艾滋病药物靶点以及艾滋病抑制剂的设计提供有益的思路。作者的实验室相继发现了一批与gp41六螺旋结构相互作用的蛋白质,进而对HIV-1 gp41六螺旋介导的膜融合过程和HIV-1感染机理有了更深入的了解。
AIDS is a serious disease that endangers human health, and HIV is the virus that causes the disease. The gp41 six-helix plays an important role in mediating membrane fusion between HIV-1 virus and target cells. Therefore, the study of gp41 binding protein will help us understand the role of gp41 in HIV-1 infection, explain the regulatory mechanism of gp41 on target cells, and find new targets of anti-HIV drugs and HIV inhibitors Provide useful ideas. A series of proteins interacting with the six-helix structure of gp41 have been found in the laboratory of the authors, which in turn has gained a better understanding of the six-helix-mediated membrane fusion process of HIV-1 and the mechanism of HIV-1 infection.