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为预防颅脑外科术后感染,常常采取抗生素与脱水剂并用,脱水剂多用20%甘露醇或10%甘油溶液.由于渗透性利尿剂的应用,就有可能影响抗生素的血药浓度及其在尿中的排泄.作者对脑外科术后患者应用氨噻肟唑头孢菌素(Cefmenoxime,CMX)与20%甘露醇并用,观察其尿中排泄率,血药浓度及脑脊液中的CMX浓度.研究对象有15例,男性8例女性7例,年龄从24～75岁.并用甘露醇组9例,平均年龄51.4岁;对照组7例,平均年龄60.7岁,
In order to prevent infection after craniocerebral surgery, antibiotics and dehydrating agents are often used together with 20% mannitol or 10% glycerol as dehydrating agent.As the application of osmotic diuretics, it is possible to affect the plasma concentration of antibiotics and its effect on Urinary excretion.The authors applied Cefmenoxime (CMX) and 20% mannitol to postoperative patients with brain surgery to observe their urinary excretion rate, plasma concentration and CMX concentration in cerebrospinal fluid 15 cases of objects, 8 males and 7 females, aged from 24 to 75. With 9 cases of mannitol group, the average age of 51.4 years; control group of 7 patients, the average age of 60.7 years,