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研究人员比较了胰岛素原即胰岛素前体分子与胰岛素本身的降低血糖作用。非胰岛素依赖性糖尿病(NIDD)病人于上午9点经皮下注射胰岛素原(每公斤体重0.2U),空腹血糖浓度(247±22mg/dl[±SEM])在6小时内变为正常,升高的肝糖生成率下降。这些病人对普通胰岛素(0.2U/kg)的反应程度与上述相似,但速度较快。胰岛素原对糖清除
The researchers compared the proinsulin insulin precursor molecules and insulin itself to reduce blood sugar. Fasting plasma glucose concentrations (247 ± 22 mg / dl [± SEM]) became normal and increased within 6 hours in non-insulin dependent diabetic (NIDD) patients by subcutaneous injections of proinsulin (0.2 U / kg body weight) The glycogen formation rate decreased. These patients to ordinary insulin (0.2U / kg) the extent of the reaction similar to the above, but faster. Insulin on the sugar clearance