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目的为研究整夜完全睡眠剥夺对人心血管自主神经活动的影响。方法对18例健康青年男性进行了整夜完全睡眠剥夺。在睡眠剥夺前后采集心电图及桡动脉连续血压波形。并进行频谱分析和对各频谱成分进行标准化。心率变异(HRV)的高频(HF)代表心脏副交感神经调制,低频(LF)代表交感神经调制而低频与高频的比率(LF/HF)代表交感神经与副交感神经的平衡,血压变异(BPV)的LF代表血管交感神经调制。结果睡眠剥夺前后心率与血压无显著变化。与基础值相比,整夜睡眠剥夺后HRVLF显著增加[(67·0±13·9)%vs(59·4±15·7)%,P=0·039],HRVLF/HF也显著增加(3·8±2·3比2·7±1·7,P=0·032),HRVHF有显著降低[(22·8±10·4)%比(29·0±11·6)%,P=0·030];BPVLF有显著增加[(72·4±13·2)%比(63·2±16·5)%,P<0·001]。结论整夜完全睡眠剥夺可导致健康青年男性心血管交感神经调制增加以及心脏副交感神经调制降低。
The purpose of this study was to investigate the effects of total sleep deprivation on cardiovascular autonomic activity in humans. Methods Eighteen healthy young men were completely sleep deprived overnight. Before and after sleep deprivation ECG and radial artery continuous blood pressure waveform acquisition. And perform spectrum analysis and standardize the spectrum components. Heart rate variability (HFV) represents cardiac parasympathetic modulation, low frequency (LF) represents sympathetic modulation and low frequency to high frequency ratio (LF / HF) represents sympathetic and parasympathetic balance, and BPV ) LF represents vascular sympathetic modulation. Results There was no significant change in heart rate and blood pressure before and after sleep deprivation. Compared with baseline, HRVLF increased significantly after sleep deprivation (67.0 ± 13.9% vs 59.4 ± 15.7%, P = 0.039), HRVLF / HF also increased significantly (3 · 8 ± 2 · 3 vs 2 · 7 ± 1 · 7, P = 0 · 032), HRVHF was significantly lower than [22.8 ± 10 · 4]% vs 29 · 0 ± 11 · 6% , P = 0 · 030]. There was a significant increase in BPVLF (72.4 ± 13.2% vs 63.2 ± 16.5%, P <0.001). Conclusion Complete sleep deprivation overnight can result in increased cardiovascular sympathetic and unresponsive cardiac parasympathetic modulation in healthy young men.