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目的观察尼莫地平对月经期癫痫的治疗效果,并探讨尼莫地平对月经性癫痫患者血清孕酮及雌二醇水平的影响。方法随机将患者分为治疗组和对照组,对照组应用常规抗癫痫药物治疗,治疗组在应用常规抗癫痫药物治疗的同时合用尼莫地平,并对这两组的疗效进行对比观察。在用药6个月后,在患者的月经期抽血检验血清孕酮和雌二醇浓度,对比两组的血清孕酮和雌二醇浓度,并对两组患者的疗效进行对比分析。结果治疗组的治疗效果明显优于对照组,二者对比有统计学意义(χ2=7.04,P<0.01)。两组患者血清的孕酮浓度差异对比无统计学意义(t=1.51,P>0.05),两组患者血清的雌二醇浓度差异对比无统计学意义(t=1.78,P>0.05)。结论尼莫地平是辅助治疗月经期癫痫的有效方法,但对患者的血清孕酮和雌二醇水平无影响。
Objective To observe the effect of nimodipine on the treatment of menstrual epilepsy and to explore the effect of nimodipine on serum progesterone and estradiol levels in patients with menstrual epilepsy. Methods The patients were randomly divided into treatment group and control group. The control group was treated with conventional antiepileptic drugs. The treatment group was treated with conventional antiepileptic drugs while nimodipine was given. The curative effect was compared between the two groups. After 6 months of medication, serum progesterone and estradiol levels were measured at the patient’s menstrual flow, and serum progesterone and estradiol concentrations were compared between the two groups. The efficacy of the two groups was compared. Results The therapeutic effect of the treatment group was significantly better than that of the control group (χ2 = 7.04, P <0.01). There was no significant difference in serum progesterone concentrations between the two groups (t = 1.51, P> 0.05). There was no significant difference in serum estradiol levels between the two groups (t = 1.78, P> 0.05). Conclusion Nimodipine is an effective adjuvant therapy for menopausal epilepsy, but it has no effect on serum progesterone and estradiol levels in patients.