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目的探讨多核巨噬细胞浸润与食管癌的关系及其临床意义。方法观察90例生存5年以上和95例死于1年内的食管鳞癌间质中多核巨噬细胞，淋巴细胞浸润、肿瘤分化、胶原纤维增生、淋巴结内癌转移。结果癌间质中多核巨噬细胞浸润阳性在生存5年组明显高于1年内死亡组（P＜0．01）。肿瘤间质淋巴细胞浸润，淋巴结内癌转移，同时有多核巨噬细胞出现在生存5年以上组亦多于1年内死亡组。结论食管鳞癌间质内多核巨噬细胞浸润是宿主抗肿瘤的重要免疫形态学表现，可作为衡量预后的指标之一。
Objective To investigate the relationship between multinucleated macrophage infiltration and esophageal cancer and its clinical significance. Methods Multinucleated macrophages, lymphocyte infiltration, tumor differentiation, collagen fibrosis, and metastasis of lymph nodes were observed in 90 cases of esophageal squamous cell carcinoma that survived for more than 5 years and 95 cases died within 1 year. Results Positive multinucleated macrophage infiltration in the cancerous interstitium was significantly higher in the 5-year survival group than in the 1-year death group (P<0.01). Interstitial lymphocyte infiltration, metastasis of lymph nodes, and multinucleated macrophages occurred in groups that survived more than 5 years and died within more than 1 year. Conclusion Infiltration of multinuclear macrophages in esophageal squamous cell carcinoma is an important immune morphological manifestation of the host anti-tumor. It can be used as one of the indexes to measure prognosis.