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目的比较分析序贯疗法与三联疗法根除幽门螺杆菌的效果和安全性。方法 242例幽门螺杆菌感染阳性患者,随机分成对照组和观察组,各121例。对照组患者应用三疗疗法进行治疗,观察组患者应用序贯疗法进行治疗,治疗后1个月,比较两组患者幽门螺杆菌根除率、治疗有效率以及不良反应发生率。结果观察组患者幽门螺杆菌根除率为94.2%,对照组为79.3%,两组比较差异具有统计学意义(P<0.05);观察组患者治疗有效率为88.4%、对照组为73.6%,两组比较差异具有统计学意义(P<0.05);观察组患者不良反应发生率为6.6%,对照组为8.3%,两组比较差异无统计学意义(P>0.05)。结论应用序贯疗法根除幽门螺杆菌具有更加显著的幽门螺杆菌清除率,能更好的改善患者的临床症状,效果优于传统的三联疗法,是一种安全高效的治疗幽门螺杆菌的方法 ,临床应用前景广泛。
Objective To compare the efficacy and safety of sequential therapy and triple therapy in the eradication of Helicobacter pylori. Methods 242 cases of Helicobacter pylori positive patients were randomly divided into control group and observation group, 121 cases each. Patients in the control group were treated with three therapies, while patients in the observation group were treated with sequential therapy. One month after the treatment, H. pylori eradication rate, treatment response rate and incidence of adverse reactions were compared between the two groups. Results The eradication rate of Helicobacter pylori was 94.2% in observation group and 79.3% in control group, the difference was statistically significant (P <0.05). The effective rate of treatment group was 88.4% in control group and 73.6% in control group The differences between the two groups were statistically significant (P <0.05). The incidence of adverse reactions in the observation group was 6.6% and that in the control group was 8.3%. There was no significant difference between the two groups (P> 0.05). Conclusion Sequential therapies for the eradication of Helicobacter pylori have more significant H. pylori clearance rate, which can better improve the clinical symptoms of patients, the effect is better than the traditional triple therapy is a safe and efficient method of treatment of Helicobacter pylori, Clinical application of broad prospects.