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采用HPLC法对7例妇女应用布比卡因硬膜外阻滞后的药物动力学(药动学)和药效学进行研究,数据用PKBP-N_1药动学程序包经IBM-PC计算机处理,结果符合血管外开放二室模型。T_p=19±8min;C_p=1.6±0.7μg/ml;T_((1/2)β)=166±59min;AUC=273±124μg/(min·ml);V_d=2.0±0.7L/kg。测得该药的作用完善时间和麻醉持续时间分别为21±3min和104±30min。手术期间未见明显不良反应。应用测得之药动学参数估算作用完善时和局麻持续时间的血药浓度.
The pharmacokinetics (pharmacokinetics) and pharmacodynamics of bupivacaine in 7 women after epidural block were studied by HPLC. The data were processed by IBM-PC computer with PKBP-N 1 pharmacokinetic package , The result is consistent with open two-compartment model of extravascular. T_p = 19 ± 8 min; C_p = 1.6 ± 0.7 μg / ml; T_ ((1/2) β) = 166 ± 59 min; AUC = 273 ± 124 μg / (min · ml); V_d = 2.0 ± 0.7 L / kg. Measured the role of the drug to improve the duration and duration of anesthesia were 21 ± 3min and 104 ± 30min. No significant adverse reactions during surgery. Application of the measured pharmacokinetic parameters to estimate the effect of local anesthesia and the duration of the plasma concentration.