In vivo antiplasmodial activity of Bombax buonopozense root bark aqueous extract in mice infected by

• 作 者: Akuodor Godwin Christian Ezeonu Chinonvelum Thecla Essien Augustine Dick Asika Ebere Chile Chilaka Kingsley Chimsorom Nwachukwu Daniel Ckukwu Nwobodo Ndubuisi Nwobodo
• 机 构: Department of Pharmacology and Therapeutics,Faculty of Medicine,Ebonyi State University,Abakaliki P.
• 出 处: 中医杂志（英文版）
• 发表日期: 2017年4期
• 关键词: Plasmodium berghei Bombax Plant extracts Phytochemicals Toxicity tests acute

OBJECTIVE:To evaluate the in vivo antiplasmodial activity and the oral acute toxicity of the Bombax buonopozense root bark aqueous extract.METHODS:The in vivo antiplasmodial activity of the root bark aqueous extract of Bombax buonopozense against early and established rodent malaria infections in chloroquine sensitive Plasmodium berghei strain in mice was investigated,and oral acute toxicity of the aqueous root bark extract of Bombax buonopozense was also evaluated in mice.RESULTS:The findings of this study revealed significant (P ＜ 0.05) and dose dependent decrease in parasitaemia in the parasitized groups treated with varying doses of the extract (50-200 mg/kg p.o.) in both suppressive and curative tests.There was also significant decrease in parasitaemia density in the chloroquine treated group.The aqueous extract was found no toxicity in mice and the oral LDs0 was determined to be greater than 5000 mg/kg.CONCLUSION:Bombax buonopozense root bark aqueous extract possesses potent antiplasmodial activity and may therefore,serve as potential sources of new antimalarial agents.