Asymmetric synthesis of pyrrolo[1,2-a]indoles via organocatalytic [3 +2] annulation of substituted 2

• 作 者: Wulin Yang Hao Wang Zirong Pan Zhong Li Weiping Deng
• 机 构: Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science an
• 出 处: 中国化学快报（英文版）
• 发表日期: 2020年3期
• 关键词: [3 + 2] Annulation Azlactones 2-Vinylindoles Asymmetric organocatalysis Pyrrolo[

The chiral phosphoric acid catalyzed asymmetric [3+2] annulation of substituted 2-vinylindoles with azlactones has been established. This reaction represented a practical approach for the synthesis of structurally diverse pyrrolo[1,2-a]indoles with two vicinal stereocenters including one tetrasubstituted stereocenter in good yields and good stereoselectivities under mild conditions.