论文部分内容阅读
许多研究均表明女性生殖系统肿瘤的发生与细胞周期调控失常有密切关系,因此探讨细胞周期调控因子和女性生殖系统肿瘤的关系已成为目前研究的热点。Cyclin E的异常表达与女性生殖系统肿瘤的发生有关。Cyclin E是G1期蛋白,与CDK2结合后其活性被激活,使其底物Rb磷酸化,促使细胞进入S期,其表达异常可使细胞周期调控失调、细胞增殖异
Many studies have shown that the occurrence of female reproductive system tumors and cell cycle regulation disorders are closely related, therefore, to explore the relationship between cell cycle regulators and female reproductive system tumors has become the current research hot spots. Abnormal expression of Cyclin E is related to the occurrence of female reproductive system tumors. Cyclin E is a G1 phase protein that binds to CDK2 and its activity is activated, phosphorylation of its substrate Rb, to promote cells into the S phase, the abnormal expression of the cell cycle can be regulated, cell proliferation