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A series of Biginelli compounds was synthesized using TsOH as a catalyst under microwave irradiation. This simple method provided the title compounds in 86%-98% yields by the reaction of aromatic aldehydes with 1,3 carbonyl compound and urea. The structure of 4o was determined by single crystal X ray diffraction analysis.
This simple method provides the title compounds in 86% -98% yields by the reaction of aromatic aldehydes with 1,3 carbonyl compound and urea. The structure of 4o was determined by single crystal X ray diffraction analysis.