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目的 :评价 CEA、CA19- 9、CA50 、CA12 5对判别良、恶性浆膜腔积液的价值。方法 :利用 RIA和 IRMA法测定 1 5 8份浆膜腔积液中的 CEA、CA19- 9、CA12 5、CA50 浓度 ,并与正常对照组血液中的水平以及良、恶性浆膜腔积液之间的水平进行统计学比较。结果 :良性浆膜腔积液较恶性浆膜腔积液其 CA12 5水平差异无显著性意义 ;恶性浆膜腔积液中的 CEA、CA19- 9、CA50 水平显著高于良性浆膜腔积液 ,并且这三项联检能提高阳性率及特异性。结论 :CEA、CA19- 9、CA50 及联检有助于判断良、恶性浆膜腔积液 ;CA12 5在良、恶性浆膜腔积液中都会升高 ,无助于判断其良、恶性。
Objective: To evaluate the value of CEA, CA19-9, CA50 and CA12 5 in discriminating between benign and malignant serous effusions. Methods: The concentrations of CEA, CA19-9, CA12 5 and CA50 in 158 cases of serous effusions were determined by RIA and IRMA respectively. The levels of CEA, CA19, CA125 and CA50 were compared with those in the normal control group and the benign and malignant serous effusions Between the level of statistical comparison. Results: There was no significant difference in the CA12 5 level between benign and malignant serous effusions. The levels of CEA, CA19-9 and CA50 in malignant serous effusions were significantly higher than those in benign serous effusions , And these three items can improve the positive rate and specificity. Conclusion: CEA, CA19-9, CA50 and joint examination can be helpful in judging benign and malignant serous effusions. CA12 5 will be elevated in both benign and malignant serous effusions, which is not helpful in judging the benign and malignant.