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钙离子是兴奋—收缩耦联中的主要联系物质,而调节细胞内钙是调整心肌和平滑肌功能的关键。早在Ringer时代就已知道Ca~(++)的重要性,但只有在最近5～10年才认识到Ca~(++)的调节对理解肌肉的生理和病理是非常重要的基本概念。随之而来的钙通道阻滞剂(Calcium-Channel-BlocKing Agents)的发现与应用成为近年来心血管疾患药物治疗的重要进展之一。钙通道阻滞剂又称钙拮抗剂,能特异性地作用于肌细胞膜上
Calcium ions are the major linkages in excitatory-contractile coupling, and regulation of intracellular calcium is the key to regulating cardiac and smooth muscle function. The importance of Ca ~ (++) was known as early as the Ringer era, but only in the last 5-10 years has it been recognized that the modulation of Ca ~ (++) is a fundamental concept that is important for understanding the physiology and pathology of muscles. The subsequent discovery and application of calcium channel blockers (Calcium-Channel-BlocKing Agents) has become one of the important progresses in the treatment of cardiovascular diseases in recent years. Calcium channel blockers, also known as calcium antagonists, can act specifically on the muscle cell membrane