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看了人民军医1959年2月号周异群同志“磺胺类药物引起的药物热和药疹”一文以后有以下几点意见,特提出与大家商讨。(一)原文谈磺胺类药过敏的诊断:“稍为复杂者作人工诱发试验以证实。惟此试验在病情严重者(如剥脱性皮炎)仍应谨慎从事。”但从作者所举的例1来看则有些不慎重,容易给读者在应用中造成不良的影响。人工诱发试验有引起严重反应,甚至危及生命的危险。在疑似磺胺类药物过敏的病例,应先做皮肤试验(虽然此种试验阳性率低),如皮肤试验呈阴性时才能做人工诱发试验,但此试验必须从小剂量开始,以免造成恶果。我在第三疗养院工作时,有一个医生疑自己对磺胺嘧啶过敏,一次自已服了磺胺嘧啶1克,试试自己对磺胺嘧啶是否真的过敏;服药约三、四分后发生了严重的反应,若不
After reading People’s Military Medical Weekly Weekly Symposium in February 1959 and the article entitled “Drug fever and drug rash caused by sulfa drugs”, I have the following suggestions and I would like to discuss with you all. (A) of the original diagnosis of sulfonamides allergy diagnosis: “slightly complicated by artificial induction test to confirm, but this test in patients with serious conditions (such as exfoliative dermatitis) should be cautious. ” However, Example 1 point of view some careless, easy to readers in the application of adverse effects. Artificial induced tests have the potential to cause serious reactions, even life-threatening. In cases of suspected sulfonamide allergy, the skin test should be performed first (although the positive rate of this test is low), if the skin test was negative to do artificial induction test, but this test must start small dose, so as to avoid adverse effects. When I was in the third nursing home, there was a doctor who suspected he was allergic to sulfadiazine. Once he took sulfadiazine 1 gram and tried to find out whether he was really allergic to sulfadiazine. Serious reactions took about three or four minutes after taking medicine If not