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本文用抗人巨噬细胞（ＣＤ６８）单克隆抗体免疫组化方法，研究了２０例原发性ＩｇＡ肾病患者肾组织中单核／巨噬细胞浸润与肾组织学损害程度、肾活检前临床参数间的关系。以６例尸体肾组织为对照。结果显示，ＩｇＡ肾病患者肾小球内ＣＤ６８阳性细胞主要位于系膜区、肾小球囊；间质中主要位于硬化的肾小球周围，散在或呈灶性分布于肾小管之间。ＭｅａｄｏｗⅢ级和Ⅳ级者肾小球内ＣＤ６８阳性细胞数和肾间质中ＣＤ６８阳性细胞百分数显著高于对照组，ＭｅａｄｏｗⅡ级者与对照组间差异不显著。肾间质中ＣＤ６８阳性细胞百分数与肾组织学损害程度、血清肌酐浓度（Ｓｃｒ）和２４ｈ尿蛋白量之间均呈正相关；肾小球中ＣＤ６８阳性细胞数与三者之间均无相关关系。本研究结果揭示，肾组织中尤其是肾间质中浸润的单核／巨噬细胞，可能在ＩｇＡ肾病进展过程中起着重要作用。
In this study, anti-human macrophage (CD68) monoclonal antibody immunohistochemistry to study the 20 cases of primary IgA nephropathy in patients with mononuclear / macrophage infiltration and renal tissue damage degree of renal biopsy before clinical parameters Relationship between. Six cases of cadaver kidney tissue as a control. The results showed that CD68 positive cells in the glomeruli of patients with IgA nephropathy mainly located in the mesangial area and glomerular vesicles; interstitial mainly located around the glomerular sclerosis, interspersed or focal distribution between the renal tubules. The number of CD68 positive cells in renal glomerulus and the percentage of CD68 positive cells in renal interstitium in Meadow Ⅲ and Ⅳ were significantly higher than those in control group. There was no significant difference between Meadow Ⅱ and control. The percentage of CD68 positive cells in renal interstitium was positively correlated with the degree of renal histological damage, serum creatinine concentration (Scr) and 24-hour urinary protein content. There was no correlation between the number of CD68 positive cells in glomerulus and the three. The results of this study revealed that infiltration of monocytes / macrophages in renal tissues, especially in the renal interstitium, may play an important role in the progression of IgA nephropathy.