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目的:探讨急性脑梗死(气虚血瘀证)患者中西医结合治疗血清炎症介质水平的变化及临床意义。方法:将急性脑梗死(气虚血瘀证)患者80例,随机分为2组各40例。对照组予以血栓通针、拜阿司匹林肠溶片、氯吡格雷、阿托伐他汀片等治疗;观察组在对照组基础上加用补阳还五汤加减口服。2组均治疗2周,观察评估2组病例治疗前后血清白细胞介素(IL)-6、IL-10水平以及脑梗死病灶大小的变化情况。结果:治疗后,2组血清IL-6水平较治疗前明显下降(P<0.05),IL-10水平较治疗前明显上升(P<0.05);且观察组上述指标改善较对照组更显著(P<0.05)。治疗后,2组脑梗死病灶均比治疗前明显缩小(P<0.05),且观察组病灶缩小较对照组更显著(P<0.05)。结论:中西医结合治疗气虚血瘀证急性脑梗死患者疗效确切,能显著改善血清IL-6、IL-10水平,从而纠正促炎和抗炎症介质的比例失调,缩小脑梗死病灶。
Objective: To investigate the changes of serum inflammatory mediators in patients with acute cerebral infarction (Qi-deficiency and blood-stasis syndrome) treated by combining traditional Chinese and western medicine and its clinical significance. Methods: 80 patients with acute cerebral infarction (Qi-deficiency and blood-stasis syndrome) were randomly divided into two groups of 40 cases. The control group was given thrombosis, aspirin enteric-coated tablets, clopidogrel, atorvastatin tablets and other treatment; the observation group on the basis of the control group plus Buyanghuanwu decoction plus oral. The two groups were treated for 2 weeks. The changes of serum interleukin (IL) -6, IL-10 levels and infarct size in two groups before and after treatment were observed and evaluated. Results: After treatment, the level of IL-6 in the two groups was significantly lower than that before treatment (P <0.05), while the level of IL-10 in the two groups was significantly higher than that before treatment (P <0.05) P <0.05). After treatment, the infarction lesions in both groups were significantly reduced (P <0.05), and the lesion size in the observation group was more significant than that in the control group (P <0.05). Conclusion: Integrative treatment of qi deficiency and blood stasis in patients with acute cerebral infarction curative effect is exact, can significantly improve the level of serum IL-6, IL-10, so as to correct the pro-inflammatory and anti-inflammatory mediators of the imbalance and reduce the infarction lesions.