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1961年以来,明确了羊水分析对Rh因子不合妊娠的临床价值后,羊水的重要性渐被认识。同时,陆续开展了诊断胎儿疾病或胎儿成熟情况的羊水成份分析新技术。此外,在Serr(1955)、Fuchs(1956)等对羊水细胞性染色质检查等的前驱研究后,Steel和Breg(1966)成功地进行了培养羊水细胞的核型分析,Nadler(1968)对先天性代谢异常症的产前诊断取得了划时代的成就,使掌握胎儿遗传情况己经成为可能。一、遗传咨询和羊水诊断的适应症
The importance of amniotic fluid has been recognized since 1961 when the clinical value of amniotic fluid analysis for Rh-incompatibility has been established. At the same time, one after another to carry out the diagnosis of fetal disease or fetal maturity of amniotic fluid composition analysis of new technologies. In addition, Karyotype analysis of amniotic fluid cells was successfully performed by Steel and Breg (1966) after Serr (1955), Fuchs (1956) and other precursor studies on amniotic fluid chromatophysiology. Nadler (1968) Prenatal diagnosis of sexual metabolic disorders made epoch-making achievements, to grasp the genetic status of the fetus has become possible. First, genetic counseling and diagnosis of amniotic fluid indications