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目的:分析我院2013~2015年抗癫痫药物血药浓度监测(TDM)结果,为临床合理用药提供参考。方法:采用回顾性研究方法,收集1 098例次患者使用丙戊酸钠、卡马西平、苯巴比妥的TDM数据并进行统计分析。结果:1 098例次TDM结果中丙戊酸钠1 009例次,卡马西平65例次,苯巴比妥24例次,3种药品血药浓度在推荐范围内的比例分别为42.6%,64.6%,37.6%。联合用药共31例次,药物浓度均在推荐浓度范围内的8例次(25.8%)。末次给药和采血时间对TDM结果有明显影响。结论:抗癫痫药物血药浓度个体差异大,影响因素多,临床用药应综合考虑各方面因素,实施个体化给药方案,确保用药安全有效。
OBJECTIVE: To analyze the results of TCD in our hospital from 2013 to 2015, and to provide a reference for clinical rational drug use. Methods: TDM data of sodium valproate, carbamazepine and phenobarbital were collected and statistically analyzed in 1 098 patients by retrospective study. Results: In 1 098 cases of TDM, there were 1 009 cases of sodium valproate, 65 cases of carbamazepine and 24 cases of phenobarbital. The proportions of the three drugs in the recommended range were 42.6% 64.6%, 37.6%. A total of 31 cases of combination therapy, the drug concentration in the recommended concentration range of 8 cases (25.8%). Last administration and blood sampling time have a significant effect on TDM results. Conclusion: There are many individual differences in antiepileptic drugs blood concentration, many factors, clinical medication should take all factors into account, the implementation of individualized drug delivery programs to ensure safe and effective medication.