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目的:探讨乳腺癌绝经后雌激素受体(ER)和孕激素受体(PR)的表达与组织学分级、腋窝淋巴结转移、肿瘤TNM分期意义。方法:回顾98例乳腺癌绝经后患者的临床资料。分析乳腺癌绝经后ER、PR的表达与患者组织学分级、腋淋巴结转移情况及肿瘤TNM分期等预后因素之间的意义。结果:ER和PR在乳腺癌绝经后中的表达率分别为58.16%、66.33%。ER、PR在不同组织学分级的绝经后乳腺癌组织中表达差异有统计学意义(P<0.05)。腋窝淋巴结转移者ER、PR阳性表达率均低于无淋巴结转移者,差异有统计学意义(P<0.05)。不同肿瘤TNM分期乳腺癌绝经后患ER和PR的阳性表达率差异无统计学意义(P>0.05)。结论:联合检测ER、PR在乳腺癌组织中的表达,对于判断乳腺癌预后和指导治疗有临床价值。
OBJECTIVE: To investigate the expression of estrogen receptor (ER) and progesterone receptor (PR), the histological grade, axillary lymph node metastasis and TNM stage in breast cancer after menopause. Methods: The clinical data of 98 postmenopausal women with breast cancer were retrospectively reviewed. To analyze the relationship between the expression of ER and PR in postmenopausal breast cancer and the prognosis of patients with histological grading, axillary lymph node metastasis and TNM stage of tumor. Results: The expression rates of ER and PR in postmenopausal women with breast cancer were 58.16% and 66.33% respectively. The expression of ER and PR in different histological grades of postmenopausal breast cancer showed statistical significance (P <0.05). The positive rates of ER and PR in axillary lymph node metastasis were lower than those without lymph node metastasis, the difference was statistically significant (P <0.05). There was no significant difference in the positive expression rates of ER and PR between different tumor TNM staging breast cancer after menopause (P> 0.05). Conclusion: The combined detection of ER and PR in breast cancer tissue is of clinical value in judging the prognosis and guiding treatment of breast cancer.