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目的：比较氨磺必利与利培酮治疗精神分裂症的疗效及安全性。方法选取2013年6月—2014年6月收治的精神分裂症患者58例，随机分为氨磺必利组和利培酮组，每组29例。氨磺必利组给予氨磺必利治疗，利培酮组给予利培酮治疗。应用阳性和阴性症状量表（ PANSS）评定疗效，应用副反应量表（ TESS）评定不良反应。结果两组临床疗效、治疗后PANSS评分以及锥体外系反应、头痛、失眠、恶心发生率比较，差异无统计学意义（ P﹥0.05），利培酮组体质量增加发生率高于氨磺必利组，差异有统计学意义（ P﹤0.05）。结论氨磺必利与利培酮治疗精神分裂症均安全有效。“,”Objective To comPare the effect and safety of schizoPhrenia and amisulPride in treating schizoPhrenia. Methods From June 2013 to June 2014 in Rongjun HosPital of Hebei Province,a total of 58 schizoPhrenia Patients were select-ed and randomly divided into amisulPride grouP and risPeridone grouP,29 cases in each grouP. AmisulPride grouP were treated with amisulPride,risPeridone grouP were treated with risPeridone,the Positive and Negative SymPtom Scale( PANSS)and Treatment Emergent symPtoms scale( TESS)were used to evalute clinical efficacy. Results Clinical effect,PANSS scores af-ter treatment,incidence rate of extraPyramidal syndrome,headache,insomnia,nausea between the two grouPs were comPared, the differences were not statistically significant(P﹥0. 05),incidence rate of weight increase of risPeridone grouP was higher than that of amisulPride grouP,the difference was statistically significant(P﹤0. 05). Conclusion AmisulPride and risPeri-done all have saftey and significant effect.