论文部分内容阅读
目的探讨血清基质金属蛋白酶-9(MMP-9)和高敏C反应蛋白(hs-CRP)在出血性脑梗死(HI)患者中的变化及临床意义。方法 52例患者检查明确诊断的HI住院患者,按临床神经功能缺损程度分级,在入院后第1,7,14天分别测定血清MMP-9和hs-CRP含量。结果 1 d、7 d、14 d血清MMP-9和hs-CRP的含量与对照组相比均明显增高,两者差异有统计学意义(P<0.01)。与1 d相比,轻度神经功能缺损患者血清MMP-9和hs-CRP含量均在7 d时显著增高(P<0.05或P<0.01),14 d时出现下降趋势;而中、重度神经功能缺损患者血清MMP-9和hs-CRP含量均在7 d时非常显著增高(P<0.01),14 d时则出现显著的下降(P<0.05或P<0.01)。血清中MMP-9与hs-CRP含量呈显著正相关。结论 MMP-9和hs-CRP可作为HI的早期诊断和判断病情及预后的指标之一。
Objective To investigate the changes and clinical significance of serum matrix metalloproteinase-9 (MMP-9) and high-sensitivity C-reactive protein (hs-CRP) in patients with hemorrhagic cerebral infarction (HI) Methods 52 patients with definite diagnosis of HI inpatients were divided into clinical neurological deficits, serum MMP-9 and hs-CRP levels were measured on the 1st, 7th and 14th days after admission. Results Serum levels of MMP-9 and hs-CRP at 1 d, 7 d and 14 d were significantly higher than those in the control group (P <0.01). The levels of serum MMP-9 and hs-CRP in patients with mild neurological deficit increased significantly at 7 days (P <0.05 or P <0.01) and decreased at 14 days The levels of serum MMP-9 and hs-CRP in patients with functional impairment were significantly increased (P <0.01) on the 7th day and significantly decreased on the 14th day (P <0.05 or P <0.01). Serum MMP-9 and hs-CRP content was significantly positively correlated. Conclusions MMP-9 and hs-CRP can be used as one of the indicators of early diagnosis and prognosis of HI.