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川芎嗪对整体动物的作用是使心肌收缩性加强,心输出量增加,对离体动物心脏的作用则相反。该药作为一种钙拮抗剂,对缺氧性心脏舒张功能障碍的影响,尚未见报道。本文报告在心肌缺氧前和缺氧时川芎嗪的作用。 一、材料与方法 用改良的Langendorff法灌流离体豚鼠冠状动脉,缺氧前灌流液PO2达450mmHg,缺氧时其PO2为150mmHg。连续记录左心室内压(LVSP),左心室内压变化最大速度(LV dP/dt max)、心率(HR)及冠脉流量(Q)。按照Weiss等提出的方法测定心室等容舒张期压力下降时间常数T值(ms)。 20只豚鼠,雌雄不拘,体重340±50g,分为两
Tetramethylpyrazine on the role of the overall animal is to enhance myocardial contractility, cardiac output increased, the role of isolated animal heart is the opposite. The drug as a calcium antagonist, hypoxemic diastolic dysfunction, has not been reported. This article reports the role of ligustrazine before and during hypoxia. Materials and Methods Perfusion of isolated guinea pig coronary arteries with a modified Langendorff method, perfusion PO2 up to 450mmHg before hypoxia, 150mmHg hypoxia. Left ventricular pressure (LVSP), left ventricular pressure (LV dP / dt max), heart rate (HR) and coronary flow (Q) were recorded continuously. According to the method proposed by Weiss and other ventricular end diastolic pressure drop time constant T value (ms). Twenty guinea pigs, both male and female, weighing 340 ± 50 g divided into two