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目的 :观察狼疮性肾炎患者尿液N -乙酰 - β -D -氨基葡萄糖苷酶 (N -acetal- β -D -glucosaminidase,NAG)的变化 ,探讨其与狼疮活动度的关系。方法 :回顾性分析 5 6例狼疮性肾炎的临床资料。结果 :其中 5 2例狼疮性肾炎患者尿液NAG增高 ,敏感度 92 .8% ,行肾组织病理检查 38例中有 2 6例为Ⅳ型狼疮性肾炎患者 ,其尿液NAG均见明显增高 ,治疗后随着狼疮活动的控制 ,尿液NAG明显下降 (P <0 .0 1)。而活动度相对较低的Ⅱ型狼疮性肾炎 ,尿液NAG仅增高程度显著低于Ⅳ型狼疮性肾炎患者 (P <0 .0 1)。结论 :尿液NAG的变化可以作为评价狼疮活动程度及治疗效果的一个指标。
OBJECTIVE: To observe the changes of urinary N-acetyl-β-D-glucosaminidase (NAG) in patients with lupus nephritis and investigate its relationship with lupus activity. Methods: A retrospective analysis of 56 cases of lupus nephritis clinical data. Results: 52 cases of lupus nephritis patients with increased urine NAG, sensitivity 92.8%, line renal pathological examination of 38 cases, 26 cases of type Ⅳ lupus nephritis patients, the urine NAG were significantly higher After treatment, with the control of lupus activity, urine NAG decreased significantly (P <0.01). The activity of relatively low type lupus nephritis, urinary NAG increased only significantly lower than in patients with type Ⅳ lupus nephritis (P <0.01). Conclusion: The change of urine NAG can be used as an index to evaluate the degree of lupus activity and therapeutic effect.