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移植后糖尿病(PTDM)传统认为由类固醇激素引起,但有证据表明环孢素(CsA)也有致糖尿病性。作者回顾分析1987.1～1989.7间接受CsA治疗的非糖尿病肾移植病人(Ⅰ组),对其中发生PTDM者停用类固醇激素以观察效果。高血糖定义为:需用降糖药或胰岛素治疗。这些降糖制剂只用于连续3次空腹血糖>200mg/dl者。免疫抑制方案:术后头7～14天用抗淋巴细胞球蛋白(ALG),围手术期硫唑嘌呤(Aza)负荷量5mg/kg,随后按2mg/Kgd,并据骨髓耐受情况调整,术后头4天采用递减型静点甲基强的松龙,分别为:60mg/4小时、60mg/6小时、60mg/8小时、60mg/12小时,随后按1mg/kg.d服强的松(Pred),至术后第10天,递减至30mg/d,术后6个
Posttransplantation of diabetes (PTDM) is traditionally thought to be caused by steroid hormones, but there is evidence that cyclosporine (CsA) is also diabetic. The authors retrospectively analyzed patients with non-diabetic renal transplantations (group I) receiving CsA between 1987.1 and 1989.7 and steroids were discontinued in patients with PTDM to observe the effect. High blood sugar is defined as: the need for hypoglycemic agents or insulin treatment. These hypoglycemic agents only for three consecutive fasting blood glucose> 200mg / dl. Immunosuppressive regimen: Anti-lymphocyte globulin (ALG), perioperative azathioprine (Aza) loading 5 mg / kg, followed by 2 mg / Kgd were administered 7 to 14 days after surgery and adjusted for bone marrow tolerance, The first 4 days after use of decreasing type static methylprednisolone, respectively: 60mg / 4 hours, 60mg / 6 hours, 60mg / 8 hours, 60mg / 12 hours, followed by 1mg / kg.d service strong (Pred), to 10 days after surgery, decreased to 30mg / d, after 6 months