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目的探讨盐酸氨溴索注射液治疗老年支气管炎急性发作的临床疗效。方法选取2014年5月—2015年5月上高县人民医院收治的老年支气管炎急性发作患者80例,按照治疗方法不同分为试验组与对照组,各40例。对照组患者予以常规治疗,试验组患者在对照组基础上予以盐酸氨溴索注射液治疗。观察两组患者临床疗效、治疗前后肺功能指标〔第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、第1秒用力呼气容积占肺活量的百分比(FEV1/FVC)〕及不良反应发生情况。结果试验组患者总有效率高于对照组,差异有统计学意义(P<0.05);治疗前两组患者FEV1、FVC、FEV1/FVC比较,差异无统计学意义(P>0.05),治疗后试验组患者FEV1、FVC、FEV1/FVC高于对照组,差异有统计学意义(P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论盐酸氨溴索注射液治疗老年支气管炎急性发作的临床疗效显著,可有效改善患者肺功能,且不良反应少,安全性高。
Objective To investigate the clinical efficacy of ambroxol hydrochloride injection in the treatment of acute exacerbation of senile bronchitis. Methods From May 2014 to May 2015, 80 patients with senile bronchitis who were admitted to Shanggao People’s Hospital were divided into experimental group and control group according to different treatment methods, 40 cases in each group. Patients in the control group were treated routinely, and patients in the test group were given ambroxol hydrochloride injection on the basis of the control group. The clinical efficacy, the pulmonary function parameters (FEV1, FVC, FEV1 / FVC) and adverse reactions before and after treatment were observed. What happened? Results The total effective rate of the experimental group was higher than that of the control group (P <0.05). There was no significant difference in FEV1, FVC and FEV1 / FVC between the two groups before treatment (P> 0.05) The FEV1, FVC and FEV1 / FVC in the experimental group were significantly higher than those in the control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion Ambroxol hydrochloride injection for the treatment of acute exacerbation of senile bronchitis has significant curative effect, which can effectively improve pulmonary function, with less adverse reactions and high safety.