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脑干是中枢神经系统中的一个重要部位,参与心血管反射,例如压力感受性反射和外周化学感受性反射。孤束核和延髓头端腹外侧是脑干中重要的两个部位,在心血管自主调节中扮演重要角色。神经递质血管紧张素II能通过活化一些通路,诱导产生活性氧簇,进而参与脑干心血管反射。研究表明,在中枢神经系统中,活性氧簇与一些病理疾病相关,例如高血压、心衰竭和睡眠性呼吸暂停。然而,活性氧簇在脑干心血管反射中的作用目前尚不明确。本文主要就最近关于活性氧簇在脑干中压力感受性反射和外周化学感受性反射中作用的一些发现进行综述及讨论。
The brain stem is an important site in the central nervous system and participates in cardiovascular reflexes such as baroreflex and peripheral chemoreflex. The solitary nucleus and the rostral ventrolateral medulla are two important parts of the brain stem and play an important role in cardiovascular autonomic regulation. Neurotransmitter angiotensin II can activate some pathways, induce the generation of reactive oxygen species, and then participate in cardiovascular reflexes. Studies have shown that in the central nervous system reactive oxygen species are associated with a number of pathological conditions such as hypertension, heart failure and sleep apnea. However, the role of reactive oxygen species in brainstem cardiovascular reflexes is not yet clear. This review summarizes and discusses some recent findings on the role of reactive oxygen species in pressure-sensitive and peripheral chemosensory reflexes in the brainstem.