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目的：探讨AAT异质体对AFP阴性肝癌的诊断价值。方法：采用豌豆凝集素亲和交叉免疫电泳法，检测78例原发性肝癌（21例AFP≤20μ／L）、20例慢性肝病及29例正常对照的血清AAT异质体。数据处理用配对资料t检验及x2检验。结果：肝癌组AAT-RP百分比显著高于慢性肝病组及对照组（P＜0.05）。AFP≤20μg／L与AFP＞20μg／L肝癌患者之AAT-RP的百分比差异大显著性（P＞0.05）。AAT—RP对肝癌的敏感性为66.67％、特异性为75.00／、阳性预测值高达91.23％。对AFP≤20μg／L及AFP＞20μg／L肝癌的敏感性、特异性、阳性预测值均差异无显著性（P＞0.05）。结论;无论AFP浓度是否升高，检测AAT异质体都有助于肝癌的临床诊断。
Objective: To investigate the diagnostic value of AAT heteroplasms in AFP-negative liver cancer. METHODS: Serum AAT heteroplasms were detected in 78 cases of primary liver cancer (21 cases of AFP≤20μ/L), 20 cases of chronic liver disease, and 29 cases of normal controls using pea lectin affinity affinity immunoelectrophoresis. Paired data t-test and x2 test were used for data processing. Results: The percentage of AAT-RP in liver cancer group was significantly higher than that in chronic liver disease group and control group (P<0.05). The percentage of AAT-RP in patients with AFP ≤20μg/L and AFP>20μg/L was significantly different (P>0.05). The sensitivity of AAT-RP to liver cancer was 66.67%, the specificity was 75.00/, and the positive predictive value was as high as 91.23%. The sensitivity, specificity, and positive predictive value of AFP ≤20μg/L and AFP>20μg/L liver cancer were not significantly different (P>0.05). CONCLUSIONS: Detection of AAT heteroplasmy contributes to the clinical diagnosis of liver cancer, regardless of whether the AFP concentration is elevated.