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控制性超排卵(COH)是目前常规体外授精-胚胎移植 (IVF-ET)程序中不可缺少的重要步骤。所谓控制性超排卵是指以药物的手段在可控制的范围内诱发多卵泡的发育和成熟,从而为一系列的辅助生殖技术(ART)奠定基础。20余年来,随着ART的不断开展与深入研究,用于促超排卵的药物有了很大的发展,COH方案和监测方法的研究也日益深入。本文主要对COH的药物、方案及监测方法进行综述。 1 COH的常用药物随着ART技术的进步,现在可提供超排卵的药物增多, 手段也更加丰富。这些药物包括克罗米芬(CC)、促性腺激素
Controlled superovulation (COH) is an indispensable and important step in routine IVF-ET procedures. The so-called controlled ovarian hyperstimulation refers to the use of drugs in the controlled range induced multi-follicle development and maturation, which laid the foundation for a series of assisted reproductive technology (ART). More than 20 years, with the continuous and intensive research of ART, the drugs used to promote superovulation have been greatly developed, and the research of COH program and monitoring method has been deepening. This article mainly reviews the drugs, protocols and monitoring methods of COH. 1 COH commonly used drugs With the progress of ART technology, can now provide more drugs ovarian hyperstimulation, means more abundant. These drugs include clomiphene citrate (CC), gonadotropins