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目的比较手术结合瘤腔局部缓释化疗和手术结合静脉化疗治疗脑胶质瘤的效果。方法回顾分析我院2003年2月至2005年4月间胶质瘤病例48例,其中手术结合瘤腔局部缓释化疗治疗胶质瘤20例,设为A组,手术结合静脉化疗治疗胶质瘤28例,设为B组,分别比较两组有效率、中位生存期、1年控制率。结果A、B两组有效率分别为85.0%和53.6%,中位生存时间分别为(49±19.75)周和(36±13.96)周,1年肿瘤控制率分别为85.0%和57.1%,三种指标两组间差异均有统计学意义(P<0.05)。结论手术结合瘤腔缓释化疗比手术结合静脉化疗获得了更为满意的疗效。
Objective To compare the effect of surgery combined with local slow-release chemotherapy and surgery combined with intravenous chemotherapy in the treatment of glioma. Methods A retrospective analysis of 48 cases of gliomas in our hospital from February 2003 to April 2005, of which 20 cases of glioma combined with local slow-release chemotherapy for the treatment of gliomas, A group, surgery combined with intravenous chemotherapy for glial Tumor in 28 cases, as the B group, were compared two groups of effective, median survival, 1 year control rate. Results The effective rates of group A and group B were 85.0% and 53.6%, respectively. The median survival time was (49 ± 19.75) weeks and (36 ± 13.96) weeks respectively. The tumor control rates at 1 year were 85.0% and 57.1% There was significant difference between the two groups (P <0.05). Conclusions Surgery combined with sustained-release chemotherapy in the tumor is more satisfactory than surgery combined with intravenous chemotherapy.