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神经松弛药物可以引起人体粒细胞缺乏症和肝内氨基转移酶的释放。应用低效价神经松弛药物时这种作用最为常见。这可能是由于此类药物对血液和肝细胞的直接毒性作用所致。作者用人神经胶质瘤细胞和小白鼠成纤维细胞作为研究材料,用含有胎牛血清的一种改良的特殊培养基。神经松弛药物选用氯丙嗪,三氟拉嗪,氟奋乃近,氨砜噻碗,氟哌啶醇,甲硫哒嗪,克塞平和吗啉吲酮共八种。配成不同浓度分别加入细胞培养基中,然后观察它们对细胞生长的抑制作用,形态学的
Nerve relaxants can cause human agranulocytosis and intrahepatic aminotransferase release. This effect is most common when low potency nerve relaxants are used. This may be due to the direct toxic effects of such drugs on blood and hepatocytes. The authors used human glioma cells and mouse fibroblasts as experimental materials, using a modified special medium containing fetal calf serum. Nerve relaxant drugs selected chlorpromazine, trifluoperazine, flufenamic close, thiophene thiamine, haloperidol, thioridazine, celecoxib and morpholone total of eight. Dubbed different concentrations were added to the cell culture medium, and then observe their inhibitory effect on cell growth, morphological