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目的探讨盐酸川芎嗪联合贝那普利治疗糖尿病肾病(DN)的临床效果。方法 100例糖尿病肾病患者根据治疗方式的不同分为对照组与观察组,每组50例。对照组给予贝那普利治疗,观察组在对照组的基础上给予盐酸川芎嗪治疗,观察两组治疗结束后尿蛋白、肾脏功能、血脂改善情况。结果两组患者治疗后的24 h尿微白蛋白排泄率、24 h尿蛋白含量变化、总胆固醇、三酰甘油、尿素氮、血清肌酐的变化比较,差异具有统计学意义(P<0.05)。结论盐酸川芎嗪联合贝那普利治疗糖尿病肾病临床效果确切,能显著降患者低尿蛋白含量,值得临床推广应用。
Objective To investigate the clinical effect of tetramethylpyrazine hydrochloride combined with benazepril on diabetic nephropathy (DN). Methods 100 patients with diabetic nephropathy were divided into control group and observation group according to the different treatment methods, 50 cases in each group. The control group was treated with benazepril. The observation group was given tetramethylpyrazine hydrochloride on the basis of the control group. Urinary protein, renal function and blood lipid were observed after treatment. Results The 24 h urine microalbumin excretion rate, 24 h urinary protein level, total cholesterol, triglyceride, urea nitrogen and serum creatinine in two groups after treatment were significantly different (P <0.05). Conclusion Ligustrazine hydrochloride combined with benazepril treatment of diabetic nephropathy clinically effective, can significantly reduce patients with low urinary protein content, worthy of clinical application.