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目的探讨基质金属蛋白酶22蛋白(MMP22)在喉癌中的表达及临床意义。方法选用Medline、Embase、中国学术期刊网全文数据库、万方数据库和维普数据库等数据库,全面检索国内外已发表的相关文献,最终进入系统评价的病例对照研究文献有7篇。应用Meta分析软件对各研究原始数据进行统计学处理,计算合并OR及95%CI。结果 Meta分析显示,与喉正常组织相比,MMP22蛋白在喉癌中呈高表达[OR=24.30,(95%CI:13.14～44.92),P<0.01];与高分化喉癌中MMP22蛋白对比,中、低分化的喉癌中MMP22蛋白呈高表达[OR=0.24,(95%CI:0.13～0.43),P<0.01];与无淋巴结转移的喉癌相比,伴淋巴结转移的喉癌中MMP22蛋白呈高表达高表达[OR=0.31,(95%CI:0.16～0.57),P<0.01]。结论 MMP22蛋白高表达可能在喉癌的发生、发展及预后中起重要作用。
Objective To investigate the expression and clinical significance of matrix metalloproteinase-22 (MMP22) in laryngeal carcinoma. Methods The databases of Medline, Embase, Chinese Academic Journal Net Full-text Database, Wanfang Database and VIP Database were selected for comprehensive search of the published literature at home and abroad, and finally included in the systematic reviews of case-control literature 7. Meta-analysis software was used to analyze the raw data of each study, and the combined OR and 95% CI were calculated. Results Meta-analysis showed that MMP22 protein was highly expressed in laryngeal carcinoma compared with normal laryngeal tissues [OR = 24.30 (95% CI: 13.14-44.92, P <0.01]; compared with MMP22 protein in well-differentiated laryngeal carcinoma (OR = 0.24, (95% CI: 0.13-0.43), P <0.01]. Compared with laryngeal carcinoma without lymph node metastasis, laryngeal carcinoma with lymph node metastasis MMP22 protein was overexpressed [OR = 0.31, (95% CI: 0.16-0.57), P <0.01]. Conclusion The high expression of MMP22 protein may play an important role in the occurrence, development and prognosis of laryngeal cancer.