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能量代谢紊乱是2型糖尿病及肥胖发生的根本病因,如何从分子水平上研究能量的储存与利用是近年来的研究热点,也是治疗糖尿病、肥胖等代谢综合征迫切需要解决的问题。腺苷酸活化蛋白激酶(AMP-activated protein kinase,AMPK)是一种保守的异源三聚体蛋白质激酶,在各组织中均有分布。AMPK具有多种功能:调控细胞生长和增殖、建立和维持细胞极性、调节动物寿命、调节生物节律等。然而,AMPK最主要的功能
Energy metabolism disorder is the fundamental cause of type 2 diabetes and obesity. How to study the storage and utilization of energy at the molecular level is a hot research topic in recent years. It is also an urgent problem to be solved in the treatment of metabolic syndrome such as diabetes and obesity. AMP-activated protein kinase (AMPK) is a conserved heterotrimeric protein kinase distributed in all tissues. AMPK has a variety of functions: regulating cell growth and proliferation, establishing and maintaining cell polarity, regulating animal lifespan, and regulating circadian rhythms. However, AMPK is the most important feature