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目的：观察大剂量法莫替丁与奥美拉唑治疗消化性溃疡急性大出血的疗效。方法：６０例急诊内镜窥示有活动性出血或新近出血征象的消化性溃疡病人，随机分为２组。法莫替丁组（男性２７例，女性３例，年龄４６±ｓ１７ａ）接受法莫替丁４０ｍｇ加生理盐水２０ｍＬ，ｉｖ，ｑ１２ｈ，连续３ｄ，奥美拉唑组（男性２６例，女性４例，年龄４５±１６ａ）接受奥美拉唑４０ｍｇ，ｉｖ，ｑ１２ｈ，连续３ｄ。结果：２组病人均止血成功。法莫替丁无不良反应。２组病人的输血量、大便隐血转阴天数、住院无数均无显著差异（Ｐ＞０．０５）。结论：大剂量法莫替丁治疗消化性溃疡急性大出血的疗效与奥美拉唑相似。
Objective: To observe the efficacy of high-dose famotidine and omeprazole in the treatment of peptic ulcer acute hemorrhage. Methods: Sixty patients with peptic ulcer who had active bleeding or recent hemorrhage during endoscopy were randomly divided into two groups. Famotidine group (27 males, 3 females, age 46 ± s17a) received famotidine 40mg plus normal saline 20mL iv, q12h, 3d, omeprazole group (26 males and 4 females , Age 45 ± 16a) received omeprazole 40mg, iv, q12h, continuous 3d. Results: Two groups of patients had hemostatic success. Famotidine no adverse reactions. There was no significant difference between the two groups in the amount of blood transfusion, number of occult blood and cloudy days, and countless number of inpatients (P> 0.05). Conclusions: The efficacy of high-dose famotidine in the treatment of peptic ulcer acute hemorrhage is similar to that of omeprazole.