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目的利用表观扩散系数(ADC)来评价肺癌的组织学特征。方法28例肺癌患者,其中男性18例,女性10例,年龄25～79岁,平均年龄52岁。行扩散加权成像(DWI)检查并测量病灶的ADC,方差分析比较不同组织学类型肺癌ADC间的差别。对11例外科切除的肺癌病灶ADC与细胞密度进行相关性分析。结果鳞癌、腺癌、小细胞癌平均ADC分别为(1.67±0.20)×10-3mm2/s、(2.08±0.28)×10-3mm2/s、(1.76±0.21)×10-3mm2/s,腺癌的ADC明显高于鳞癌及小细胞癌(P<0.05)。肺癌ADC与细胞密度呈显著负相关(r=-0.71,P=0.015)。结论腺癌的ADC明显高于其他类型肺癌;ADC似乎可以鉴别肺癌的组织学类型。
Objective To evaluate the histological features of lung cancer using apparent diffusion coefficient (ADC). Methods Twenty-eight patients with lung cancer, including 18 males and 10 females, aged from 25 to 79 years and mean age of 52 years. Diffusion-weighted imaging (DWI) was performed to detect and measure the lesion ADC. Variance analysis was used to compare the differences between different histological types of lung cancer ADC. Correlation analysis of ADC and cell density in 11 cases of surgical resection of lung cancer was performed. Results The average ADC of squamous cell carcinoma, adenocarcinoma and small cell carcinoma were (1.67 ± 0.20) × 10-3mm2 / s, (2.08 ± 0.28) × 10-3mm2 / s and (1.76 ± 0.21) × 10-3mm2 / The ADC of adenocarcinoma was significantly higher than that of squamous cell carcinoma and small cell carcinoma (P <0.05). Lung cancer ADC and cell density was significantly negatively correlated (r = -0.71, P = 0.015). Conclusion The ADC of adenocarcinoma is significantly higher than that of other types of lung cancer; ADC seems to identify the histological type of lung cancer.