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关于心绞痛祖国典藉早有记载。国外亦在1772年即由Heberden氏作了典型的描述,但在治疗学上进展很慢。迄今尚未获得理想的药物。1867年Brunton报告了Amyl nitrite对心绞痛的疗效。十二年后(1879年)Murrell报告了硝酸甘油抗心绞痛的作用。此后尽管屡有新药报道,硝酸甘油仍不失为治疗心绞痛的首选药物。但此药作用时间短暂,对较长时间扩张冠状血管、改善心肌血运、预防心绞痛的复发均乏理想效果。因此,多年来均致力于寻找所谓长效血管扩张剂,试图弥补其不足。二硝酸异山梨醇(Isosorbide Dinitrate)(ISD-N)(商品名Isordll,国产商品名消心痛)是一种有
On the angina motherland Code has long been documented. Abroad also in 1772 by Heberden’s made a typical description, but progress in the treatment of very slow. So far no ideal medicine has been obtained. Brunton 1867 reported the efficacy of Amyl nitrite on angina pectoris. Twelve years later (1879) Murrell reported on the role of nitroglycerin in anti-anginal pectoris. Since then, despite repeated reports of new drugs, nitroglycerin is still the drug of choice for the treatment of angina. However, the short acting time of the drug, the expansion of coronary vessels for a long time to improve myocardial blood supply, prevention of recurrence of angina are lack of ideal results. Therefore, over the years are committed to looking for so-called long-acting vasodilators, trying to make up for its deficiencies. Isosorbide Dinitrate (ISD-N) (Isordll, a trade name for heartburn) is a