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目的：建立测定血浆中巴洛沙星浓度的HPLC法，比较巴洛西林分散片与巴洛沙星普通片在健康大鼠体内药代动力学差异。方法选择12只健康大鼠分为两组，分别单剂量口服巴洛沙星分散片与巴洛沙星普通片各10mg，采用高效液相色谱法检测巴洛沙星的血药浓度。结果巴洛沙星分散片与巴洛沙星普通片主要药代动力学参数 Cmax分别为（93.0±2.4）μg/L和（89.0±3.1）μg/L，tmax分别为（1.30±0.21）h和（1.80±0.11）h，t1/2分别为（4.68±1.65）h和（4.85±1.42） h，AUC0∞分别为（953.0±27.8）μg/（μg/l）和（836.0±30.1）μg/（μg/l），AUC01分别为（856.0±24.2）μg/（μg/l）和（735.0±32.5）μg/（μg /l）。结论巴洛沙星分散片tmax、t1/2小于普通片，AUC0∝、Cmax高于普通片，说明巴洛沙星分散片具有一定的速释优点，明显优于普通片。“,”Objective To develop a HPLC method for determination of balofloxacin in human plasma and compare the pharmacokinetics of balofloxacin dispersible tablets and balofloxacin tablets in healthy volunteers.Methods Twelve healthy male volunteers were selected and divided into two groups,who received a single oral dose of 10 mg balofloxacin sustained release tablets and balofloxacin tablets respectively.The plasma concentrations of balofloxacin were determined by HPLC Results Balofloxacin dispersible tablets and balofloxacin tablets in the main pharmacokinetic parameters of Cmax were(93±2.4)μg/L and (89±3.1)μg/L,Tmax were (1.30±0.21)h and (1.80±0.11)h, t1/2 were(4.68±1.65)h and (4.85±1.42)h,AUC0∞) were (953±27.8)μg/(μg/l) and (836±30.1)μg/(μg/l), AUC01 were (856 ±24.2)μg/(μg/l) and (735±32.5)μg/(μg/l). Conclusion Balofloxacin dispersible tablets Tmax,t1/2 is less than common tablets, AUC0∞, Cmax higher than ordinary tablets, indicate that it has certain advantages of quick release balofloxacin dispersible tablets,significantly better than the ordinary tablets.