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目的评价急性心肌梗死(AMI)并泵衰竭的患者早期应用主动脉球囊反搏术(IABP)对心功能的影响。方法选取AMI并泵衰竭、入院后6h内无心源性休克发生的患者共计54例,其中IABP组27例,在直接PCI、积极药物治疗基础上早期应用IABP辅助治疗;对照组27例,给予直接PCI及积极药物治疗,若病情进展至心源性休克,则给予IABP治疗。比较两组患者住院24h内及发病后随访6月时超声心动图及血浆BNP水平。结果 IABP组与对照组24h内纽约心功能分级、左心室功能指标及血浆BNP水平无显著差异(P﹥0.05),但发病6月IABP组BNP水平显著低于对照组(P﹤0.05),超声心动图示左心室功能指标IABP组显著优于对照组(P﹤0.05)。结论早期应用IABP能显著改善AMI并泵衰竭患者心功能。
Objective To evaluate the effect of early application of aortic balloon counterpulsation (IABP) on cardiac function in patients with acute myocardial infarction (AMI) and pump failure. Methods A total of 54 patients with no cardiogenic shock within 6 hours after admission were enrolled in this study. Twenty-seven patients in IABP group received IABP adjuvant therapy on the basis of direct PCI and active drug therapy. In control group, 27 patients were given direct PCI and active drug therapy, if the progression of the disease to cardiogenic shock, then given IABP treatment. Echocardiography and plasma BNP levels were compared between the two groups within 24 hours after hospitalization and after 6 months of follow-up. Results There was no significant difference in cardiac function grade, left ventricular function index and plasma BNP level between IABP group and control group within 24 hours (P> 0.05), but BNP level in IABP group was significantly lower than that in control group (P <0.05) Cardiogram showed left ventricular function index IABP group was significantly better than the control group (P <0.05). Conclusion Early application of IABP can significantly improve cardiac function in patients with AMI and pump failure.