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目的比较小剂量硝苯地平 (N)、卡托普利 (C)、美托洛尔 (M)联合应用 (简称小剂量 NCM方案 )与单用硝苯地平、卡托普利、美托洛尔对高血压病的疗效。方法 2 40例高血压病患者停用抗高血压药物 10天 ,然后随机分为 4组 ,NCM组 12 0例采用小剂量硝苯地平 ,卡托普利、美托洛尔联合口服 ;N组 40例单用硝苯地平口服 ;C组 40例单用卡托普利口服 ;M组 40例单用美托洛尔口服。结果经过 3个月的治疗后 ,降压总有效率依次为 95 .8%、70 .0 %、75 .0 %、72 .5 % ,(P均 <0 .0 1、)。副作用发生率依次为 4.16%、2 2 .5 %、2 7.5 %、2 0 .0 % (P均 <0 .0 1) ,未见明显的电解质、血糖和血脂变化。结论小剂量硝苯地平、卡托普利、美托洛尔联合可有效提高降压疗效 ,减少副作用的发生
Objective To compare the effects of low-dose nifedipine (N), captopril (C) and metoprolol (M) in combination with low-dose NCM regimen alone with nifedipine, captopril, Efficacy of hypertension on hypertension. Method 2 40 hypertensive patients with antihypertensive drugs were discontinued for 10 days, and then randomly divided into four groups, 120 cases of NCM group with low-dose nifedipine, captopril, metoprolol combined oral; N group 40 cases were treated with nifedipine alone, 40 cases were treated with captopril alone in group C and 40 cases were treated with metoprolol alone. Results After 3 months of treatment, the total effective rate of blood pressure reduction was 95.8%, 70.0%, 75.0% and 72.5%, respectively (all P <0.01). The incidence of side effects were 4.16%, 22.5%, 25.5% and 20.0% (P <0.01), and no obvious change of electrolytes, blood glucose and blood lipids were observed. Conclusion Small doses of nifedipine, captopril, metoprolol combined can effectively reduce blood pressure and reduce the incidence of side effects