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肾上腺髓质素由 52个氨基酸组成 ,血浆AM来源于血管内皮细胞、血管平滑肌细胞及心肌细胞 ,通过旁分泌、自分泌直接与间接发挥其类激素样作用 ,舒张动脉、降低血压 ,抑制血管平滑肌迁移和增殖 ,抑制心肌肥厚 ,排钠利尿 ,参与原发性高血压 ,充血性心力衰竭 ,肺动脉高压 ,休克及体液和电解质平衡的调节机制 ,增加冠状动脉血流 ,抑制交感神经兴奋性 ,保护心肌细胞 ,减轻再灌注损伤。
Adrenomedullin is composed of 52 amino acids. Plasma AM is derived from vascular endothelial cells, vascular smooth muscle cells and cardiomyocytes. It exerts its hormone-like effects directly and indirectly through paracrine and autocrine, which can relax the artery, lower blood pressure and inhibit vascular smooth muscle Migration and proliferation, inhibition of cardiac hypertrophy, natriuresis, hypertension, congestive heart failure, pulmonary hypertension, shock and the regulation of body fluid and electrolyte balance, increase coronary blood flow, inhibit sympathetic nerve excitability, protect Myocardial cells, reduce reperfusion injury.